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Overview of new this month
Of the 125 new registrations, 71 are randomised and 4 are industry-sponsored. 40 were registered after they had already started or finished; we flag these because results from late-registered trials deserve extra scrutiny.
New spine trials registered in October
The 125 studies first posted on ClinicalTrials.gov between 1 and 31 October 2026 that are dedicated to the spine or spinal cord. Filter by topic, or narrow to randomised, industry or drug trials.
Download all 125 as a spreadsheet (CSV), or tick the box next to individual trials to download only those.
125 of 125 trials shown
Surgery & implants5
Kore Fiber PLF Study New · week 1randomised
Kolosis Bio, LLCUnited States · 75 participants · Not yet recruiting · primary completion Nov 2028
RCT · Drug / biologic · Industry
Assessing Microbiome in Primary Anterior Cervical Fusion Patients New · week 1single arm
Hospital for Special Surgery, New YorkUnited States · 76 participants · By invitation · primary completion 20 May 2027
Registered after start
A Study of LDGraft In Single Level Lumbar Interbody Fusion New · week 1Phase 1/Phase 2, single arm
Locate Bio LtdGeorgia · 25 participants · Recruiting · primary completion Oct 2027
Industry · Multicentre · Registered after start
NCT07858643 · AMBITION
Endoscopic Posterior Cervical Foraminotomy Versus Anterior Cervical Discectomy and Fusion for Cervical Radiculopathy New · week 1randomised
Central Hospital, Nancy, FranceFrance · 46 participants · Not yet recruiting · primary completion 1 Feb 2028
RCT
NCT07894159 · ENDOFOR
Comparing Lumbar Fusion With and Without Stress Endplate Augmentation in Patients With Low Bone Mass New · week 1Observational (cohort)
Xuanwu Hospital, BeijingCountry not stated · 300 participants · Not yet recruiting · primary completion 1 Dec 2029
n ≥ 200
Perioperative care15
Nurse-Led Early Standing Exercise After Lumbar Fusion in Older Adults New · week 1randomised
Xuanwu Hospital, BeijingChina · 108 participants · Completed · primary completion 10 Dec 2024
RCT · Registered after completion
Comparison of Mean Arterial Pressure After Endotracheal Intubation in Patients Undergoing Spine Surgery With Pre-emptive Nitroglycerine Versus Dexmedetomidine New · week 1randomised
Mayo Hospital LahorePakistan · 80 participants · Completed · primary completion 10 Jun 2026
RCT · Drug / biologic · Registered after completion
Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery New · week 1Phase 4, randomised, double-blind
Beijing Tsinghua Chang Gung HospitalChina · 190 participants · Not yet recruiting · primary completion Jan 2028
RCT · Drug / biologic
Intravenous Lidocaine Versus Erector Spinae Plane Block After Lumbar Arthrodesis (LIBERA) New · week 1randomised
GCS Ramsay Santé pour l'Enseignement et la RechercheFrance · 90 participants · Not yet recruiting · primary completion Apr 2028
RCT
NCT07895368 · LIBERA
Hypnosis for Pain and Nausea Reduction in Scoliosis Surgery: An Interventional Study New · week 1non-randomised
St. Olavs HospitalNorway · 30 participants · Recruiting · primary completion 30 Dec 2026
NCT07854951 · HYP-SCOL
Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar Surgery New · week 1randomised
First Affiliated Hospital of Kunming Medical UniversityChina · 90 participants · Completed · primary completion 20 Feb 2026
RCT · Drug / biologic · Registered after completion
Intravenous Dexamethasone for ESP Block Analgesia in Children Undergoing Idiopathic Scoliosis Surgery New · week 1Phase 4, randomised, quadruple-blind
Poznan University of Medical SciencesPoland · 90 participants · Not yet recruiting · primary completion 1 Dec 2027
RCT · Drug / biologic
the Effect of the Preoperative Information Method on Intraoperative Anxiety and Postoperative Outcomes in AIS Patients: a Randomized Clinical Trial New · week 1randomised
Gazi UniversityTurkey (Türkiye) · 42 participants · Completed · primary completion 1 Sep 2024
RCT · Registered after completion
Pulmonary Mechanics and Cerebral Oxygenation During Prone Lumbar Disc Surgery New · week 1Observational (cohort)
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research HospitalTurkey (Türkiye) · 100 participants · Recruiting · primary completion 30 Jan 2027
Spinal Anaesthesia Success in Patients With Previous Lumbar Spine Surgery New · week 1Observational (cohort)
Celal KayaTurkey (Türkiye) · 50 participants · Recruiting · primary completion 28 Dec 2026
Efficacy of Intrawound Vancomycin in Spine Surgery New · week 1Phase 3, randomised
Ain Shams UniversityEgypt · 416 participants · Completed · primary completion 2 May 2026
RCT · Drug / biologic · n ≥ 200 · Registered after completion
Acetazolamide to Reduce Spinal Fluid Leaks After Spine Surgery. New · week 1Phase 4, randomised
Ain Shams UniversityEgypt · 26 participants · Completed · primary completion 26 Apr 2026
RCT · Drug / biologic · Registered after completion
Intertransverse Process Block Versus Erector Spinae Plane Block for Pain Relief in Lumbar Spine Surgery New · week 1randomised
Hanoi Medical UniversityVietnam · 90 participants · Completed · primary completion 31 Aug 2026
RCT · Registered after completion
Modified Thoracolumbar Interfascial Plane Block vs Retrolaminar Block for Pain in Lumbar Spine Surgeries New · week 1randomised, double-blind
Zagazig UniversityEgypt · 42 participants · Recruiting · primary completion 1 Dec 2026
RCT · Drug / biologic · Registered after start
Pain After Microsurgical Decompression New · week 1Observational (cohort)
Aalborg UniversityDenmark · 200 participants · By invitation · primary completion 31 Dec 2028
n ≥ 200
Spinal cord injury11
Efficacy of Robotic Upper Limb Rehabilitation Training in Patients With Tetraplegia New · week 1randomised
IRCCS Sacro Cuore Don Calabria di NegrarItaly · 24 participants · Recruiting · primary completion 1 Oct 2027
RCT · Device · Registered after start
NCT07860827 · TRRAT
Cardiocentric Inotropic Optimization in Spinal Cord Injury New · week 1Early Phase 1, single arm
University of British ColumbiaCanada · 8 participants · Not yet recruiting · primary completion Jun 2030
Drug / biologic
NCT07871643 · CARDIO-SCI
Powered Exoskeleton-Assisted Walking in Persons With Spinal Cord Injury New · week 1Observational (cohort)
IRCCS San Raffaele RomaItaly · 74 participants · Completed · primary completion 15 May 2025
Device · Registered after completion
NCT07884591 · EKSO-SCI
Vibratory Genital Nerve Stimulation (vGNS) to Treat Female Sexual Dysfunction (FSD) After Spinal Cord Injury (SCI) New · week 1single arm
Samuel CramerUnited States · 20 participants · Recruiting · primary completion Jul 2028
Device
Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury New · week 1Phase 2, randomised, double-blind
Kessler FoundationUnited States · 30 participants · Recruiting · primary completion 30 Apr 2028
RCT · Device · Drug / biologic
Co-contraction and Corticoreticular Excitability in Spinal Cord Injury New · week 1single arm
Taipei Veterans General Hospital, TaiwanTaiwan · 20 participants · By invitation · primary completion 30 Jun 2027
Patterns of Rehabilitation After Spinal Cord Injury New · week 1Observational (other)
Gaziler Physical Medicine and Rehabilitation Education and Research HospitalTurkey (Türkiye) · 103 participants · Recruiting · primary completion 30 Mar 2027
Comparison Between Objective Biomechanical Cost and Perceived Physical Demand in Manual Wheelchair Users During Propulsion Tasks New · week 1single arm
Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge FrançaiseFrance · 15 participants · Recruiting · primary completion 23 Oct 2026
NCT07897214 · FFM
BreEStim Pre-trial New · week 1randomised, double-blind
The University of Texas Health Science Center, HoustonUnited States · 32 participants · Not yet recruiting · primary completion 18 Dec 2026
RCT · Device
Risk Factors for Spinal Cord Injury After Minimally Invasive Aortic Repair New · week 1Observational (cohort)
Assiut UniversityEgypt · 200 participants · Not yet recruiting · primary completion Oct 2028
n ≥ 200
NCT07896564 · SCI-AORTA
A Rehabilitation Data Collection Study in Patients With Spinal Cord Injury New · week 1Observational (cohort)
Seoul National University HospitalSouth Korea · 250 participants · Recruiting · primary completion 30 Nov 2026
n ≥ 200 · Registered after start
Neuromodulation7
Transcutaneous Spinal Cord Stimulation for Neurorehabilitation After Spinal Cord Injury New · week 1non-randomised
Ernesto LosavioItaly · 20 participants · Not yet recruiting · primary completion Nov 2027
Device
NCT07893470 · NEUROSTIM-SCI
Recovery and Safety After Epidural Spinal Cord Stimulation in People With Spinal Cord Injury New · week 1Observational (case only)
Hainan UniversityChina · 6 participants · Active, not recruiting · primary completion 30 Nov 2026
Device · Registered after start
tSCS Combined With Rehabilitation Training in Treating Paraplegic Patients After SCI New · week 1single arm
Beijing Tsinghua Chang Gung HospitalChina · 10 participants · Recruiting · primary completion 31 Dec 2026
Registered after start
NCT07907952 · tSCScwRT
Feasibility of Transcutaneous Spinal Stimulation in Rehabilitation New · week 1single arm
Janelle UngerCanada · 15 participants · Not yet recruiting · primary completion 30 Mar 2027
Device
AI-Guided Multi-Electrode Transcutaneous Spinal Cord Stimulation for Gait Rehabilitation in People With Spinal Cord Injury or Stroke New · week 1randomised, double-blind
University of Sao Paulo General HospitalBrazil · 24 participants · By invitation · primary completion Jan 2027
RCT · Device · Registered after start
Transcutaneous Spinal Cord Stimulation for Blood Pressure Augmentation Immediately After Spinal Cord Injury New · week 1single arm
Markey OlsonCountry not stated · 20 participants · Not yet recruiting · primary completion 31 Dec 2027
Device
NCT07887373 · Stim for MAP
Addressing Spasticity and Motor Function With Epidural Spinal Cord Stimulation New · week 1single arm
Kessler FoundationUnited States · 8 participants · Recruiting · primary completion 30 Jan 2029
Device
Deformity & paediatric6
Scoliosis Treatment: Evaluating Patient Suitability New · week 1Observational (cohort)
Xuanwu Hospital, BeijingCountry not stated · 300 participants · Not yet recruiting · primary completion 31 Dec 2028
n ≥ 200
NCT07891676 · STEPS
The Effect of Curve Type Determined According to the Rigo Classification on Respiratory Muscle Strength, Quality of Life, and Functional Status in Individuals Diagnosed With Adolescent Idiopathic Scoliosis. New · week 1Observational (case control)
Istanbul Physical Medicine Rehabilitation Training and Research HospitalCountry not stated · 120 participants · Not yet recruiting · primary completion Jan 2027
Evaluation of a Prehabilitation Program in Patients Requiring Scoliosis Surgery. New · week 1randomised
University Hospital, GrenobleFrance · 60 participants · Not yet recruiting · primary completion 28 Feb 2028
RCT
NCT07852286 · PHYPSYSCOL
Clinical and Biological Parameters in Adolescent Idiopathic Scoliosis New · week 1Observational (case only)
Gaziler Physical Medicine and Rehabilitation Education and Research HospitalCountry not stated · 83 participants · Not yet recruiting · primary completion 1 May 2027
Construction of a Screening and Precision Intervention System for Adolescent Idiopathic Scoliosis Based on the DIERS Spinal Moiré System New · week 1Observational (case control)
Jiawei JiangChina · 500 participants · Active, not recruiting · primary completion Dec 2026
n ≥ 200 · Registered after start
Real-World Effectiveness of Conservative Treatment in Idiopathic Scoliosis New · week 1Observational (cohort)
Istituto Scientifico Italiano Colonna VertebraleItaly · 30000 participants · Active, not recruiting · primary completion 2 Oct 2028
Device · n ≥ 200
Trauma & fracture2
MALMOS Technique for Selected Subaxial Cervical Spine Fractures New · week 1single arm
Assiut UniversityEgypt · 15 participants · Not yet recruiting · primary completion 30 Mar 2028
NCT07905573 · MALMOS
Impact of Diabetes on Patients With Osteoporotic Vertebral Compression Fractures After Vertebral Augmentation New · week 1Observational (case control)
The First Affiliated Hospital, Guangzhou University of Traditional Chinese MedicineChina · 360 participants · Completed · primary completion 30 Sep 2026
n ≥ 200 · Registered after completion
Interventional & injections10
Clinical and MRI Factors Associated With Procedural Difficulty in Lumbar TFESI New · week 1Observational (cohort)
Selcuk UniversityCountry not stated · 190 participants · Not yet recruiting · primary completion 8 Apr 2027
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation New · week 1randomised, quadruple-blind
Karolinska InstitutetSweden · 262 participants · Not yet recruiting · primary completion Jan 2030
RCT · Multicentre · n ≥ 200
NCT07895589 · SELDISC
Randomized Evaluation of Lumbar Injection Effectiveness and Function New · week 1randomised
SpinaFX Medical Inc.Country not stated · 300 participants · Not yet recruiting · primary completion 14 Jun 2028
RCT · Device · Industry · n ≥ 200
NCT07856810 · RELIEF
Radiofrequency and Pelvic Floor-Core Exercise for Chronic Low Back Pain in Women With Pelvic Floor Dysfunction New · week 1randomised
SERGIO MONTERO NAVARROSpain · 60 participants · Not yet recruiting · primary completion 31 Mar 2027
RCT · Device
PRP Versus NP Injections for Chronic Discogenic Low Back Pain New · week 1Phase 2/Phase 3, randomised, double-blind
Walter Reed National Military Medical CenterUnited States · 60 participants · Not yet recruiting · primary completion Jun 2028
RCT · Drug / biologic
Erector Spinae Plane Block With or Without Thoracolumbar Fascia Injection for Chronic Low Back Pain New · week 1randomised
Damla YürükTurkey (Türkiye) · 72 participants · Not yet recruiting · primary completion 1 Feb 2028
RCT
NCT07900347 · ESP-TLF
Sarcopenia and Interlaminar Epidural Steroid Injection Outcomes in Lumbar Spinal Stenosis New · week 1Observational (cohort)
Marmara UniversityTurkey (Türkiye) · 70 participants · Recruiting · primary completion Mar 2027
Focused Versus Multi-Target Trigger Point Injection for Chronic Myofascial Neck Pain New · week 1randomised, double-blind
Mardin Artuklu UniversityTurkey (Türkiye) · 100 participants · Not yet recruiting · primary completion 15 Jan 2028
RCT · Drug / biologic
MRI-Based Artificial Intelligence Prediction of Fluoroscopic C-Arm Angles for Lumbar Transforaminal Epidural Steroid Injections New · week 1Observational (other)
Marmara UniversityCountry not stated · 80 participants · Not yet recruiting · primary completion 1 May 2027
Does Injection Target Matter in Sacroiliac Joint Dysfunction? New · week 1Observational (cohort)
Fatih Sultan Mehmet Training and Research HospitalCountry not stated · 30 participants · Not yet recruiting · primary completion 25 Oct 2026
Other spine conditions10
Nurse-Led Exercise Program for Older Adults With Ankylosing Spondylitis New · week 1single arm
Mansoura UniversityEgypt · 50 participants · Completed · primary completion 1 Apr 2026
Registered after completion
Surface Topography and Radiographic Spinal Damage in Radiographic Axial Spondyloarthritis New · week 1Observational (cohort)
Ankara Etlik City HospitalTurkey (Türkiye) · 53 participants · Recruiting · primary completion 20 Jun 2027
Evaluation of the Statistical Validity of Cervical Spine Measurements-Including Range of Motion, Strength, and Functional Test Results-for Return to Sport in Patients Who Have Undergone Surgery for Cervical Stenosis and/or Herniation. New · week 1non-randomised
GCS Ramsay Santé pour l'Enseignement et la RechercheFrance · 60 participants · Recruiting · primary completion 20 Nov 2026
Registered after start
NCT07886112 · RC REPRO
Ivarmacitinib With or Without Celecoxib for Ankylosing Spondylitis New · week 1Phase 4, randomised
Peking University Third HospitalCountry not stated · 138 participants · Not yet recruiting · primary completion 31 Dec 2029
RCT · Drug / biologic
Posture Exercises in Ankylosing Spondylitis New · week 1randomised
Mustafa AkçaTurkey (Türkiye) · 54 participants · Not yet recruiting · primary completion 1 Nov 2027
RCT
NCT07879157 · AS-POSTURE
Plantar Fascia Thickness and Pedobarometric Parameters in Sacroiliac Joint Dysfunction New · week 1Observational (case control)
Dokuz Eylul UniversityTurkey (Türkiye) · 52 participants · Completed · primary completion 1 Sep 2026
Registered after completion
Association of Subcutaneous Fat Index, Paraspinal Muscle Characteristics, and Facet Morphology With Lumbar Facet Joint Degeneration New · week 1Observational (cohort)
Marmara UniversityTurkey (Türkiye) · 300 participants · Recruiting · primary completion 1 Jun 2027
n ≥ 200
Neuropathic Pain Severity and Its Association With Radiological Findings in Lumbar Spinal Stenosis New · week 1Observational (other)
Marmara UniversityTurkey (Türkiye) · 100 participants · Recruiting · primary completion Feb 2027
SLAMF1 Gene Expression in Ankylosing Spondylitis New · week 1Observational (case control)
Assiut UniversityCountry not stated · 100 participants · Not yet recruiting · primary completion 30 Oct 2027
Phase Ia Study of MST-931 in Healthy Adult Subjects New · week 1Phase 1, randomised, quadruple-blind
Mabsoft Therapeutics (Shanghai) Co., Ltd.Australia · 32 participants · Recruiting · primary completion 30 Jul 2027
RCT · Drug / biologic · Industry
Rehab & conservative care59
Application of Chain Management Based on the IMB Model in Patients With Kinesiophobia Following Lumbar Fusion Surgery New · week 1non-randomised
Jiawei JiangChina · 104 participants · Recruiting · primary completion 1 Feb 2028
Registered after start
The Association Between Smartphone Overuse and Mechanical Neck Pain Among Galala University Students New · week 1Observational (other)
Cairo UniversityEgypt · 36 participants · Recruiting · primary completion 20 Nov 2026
Registered after start
NCT07879313 · CFME/ CVA/ UCS
Comparative Effects of Manuel and Percussion Massage in İndividuals With Neck Pain New · week 1randomised
Tarsus UniversityTurkey (Türkiye) · 28 participants · Completed · primary completion 10 Aug 2025
RCT · Registered after completion
Comparative Effects of METs and Core Strengthening on Anterior Sacral Torsion Dysfunction New · week 1randomised
University of Management and Technology LahorePakistan · 48 participants · Active, not recruiting · primary completion 31 Dec 2026
RCT
Correlation Between Forward Head Posture and Executive Functions in Cervical Radiculopathy New · week 1Observational (other)
Cairo UniversityEgypt · 80 participants · Not yet recruiting · primary completion Jan 2027
Body and the Brain: Cortical Reactivity and Cognitive-Affective Regulation to Experimental Pain. New · week 1Observational (case control)
Oregon Health and Science UniversityUnited States · 26 participants · Completed · primary completion 1 Apr 2022
Comparing Patient-Reported Symptoms to Objective Neck Range of Motion and Physical Capacity in Women With Chronic Neck Pain. New · week 1Observational (cohort)
Borna FarhoomandCountry not stated · 96 participants · Not yet recruiting · primary completion 25 Dec 2026
Therapeutic Exercise Plus Pain Neuroscience Education for Chronic Low Back Pain New · week 1randomised
Qingdao Municipal HospitalChina · 60 participants · Completed · primary completion 15 Oct 2025
RCT · Registered after completion
Dynamic Versus Traditional Core Strengthening Exercises in Patients With Chronic Non-specific Low Back Pain New · week 1randomised
University of LahorePakistan · 70 participants · Completed · primary completion 14 Apr 2026
RCT · Registered after completion
NCT07884396 · CNLBP
Biofeedback Exercises Versus Mulligan Concept on Pain, Mobility, and Posture in Females With Mechanical Neck Pain New · week 1randomised
Al Hayah University In CairoEgypt · 50 participants · Recruiting · primary completion 6 Dec 2026
RCT
The Effect of Tecar Therapy in Patients With Chronic Neck Pain New · week 1randomised
Ankara City Hospital BilkentTurkey (Türkiye) · 59 participants · Completed · primary completion 10 Dec 2023
RCT · Device · Registered after completion
McGill Stabilization Exercises Versus Pilates for Chronic Low Back Pain New · week 1randomised
University of Management and Technology LahorePakistan · 40 participants · Not yet recruiting · primary completion 31 Dec 2026
RCT
Upper Extremity Exercise Capacity in Chronic Non-specific Neck Pain New · week 1Observational (case control)
Karabuk UniversityTurkey (Türkiye) · 58 participants · Recruiting · primary completion 20 Dec 2026
Registered after start
Visual Feedback-Assisted Sensorimotor Training in Chronic Nonspecific Low Back Pain New · week 1randomised
Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research HospitalTurkey (Türkiye) · 70 participants · Not yet recruiting · primary completion 20 Mar 2027
RCT
NCT07887789 · VF-SMT
Effects of Progressive Neck Motor Control Exercises With and Without Conventional Therapy in Text Neck Syndrome.(PNMCE-TNS) New · week 1randomised
University of Management and Technology LahorePakistan · 44 participants · Not yet recruiting · primary completion 31 Dec 2026
RCT
NCT07892131 · Yes
Effect of Added Load on Map-Based Proprioceptive Training in Chronic Neck Pain New · week 1randomised
Hacettepe UniversityTurkey (Türkiye) · 30 participants · Completed · primary completion 31 Jan 2024
RCT · Registered after completion
The Clinical Efficacy and Multimodal Imaging Mechanism of the Knot-tying Technique in the Treatment of Chronic Neck Pain New · week 1randomised, quadruple-blind
Li JuntaoCountry not stated · 60 participants · Not yet recruiting · primary completion 31 Dec 2028
RCT
Digital Use, 24-Hour Movement Behaviors, and Myofascial Release in University Students With Neck Pain New · week 1randomised
Karabuk UniversityTurkey (Türkiye) · 56 participants · Not yet recruiting · primary completion 31 Oct 2027
RCT
Comparison of Suboccipital Release and Muscle Energy Technique in Subjects With Mechanical Neck Pain and Forward Head Posture New · week 1randomised, double-blind
King Edward Medical UniversityPakistan · 76 participants · Not yet recruiting · primary completion 15 Dec 2026
RCT
NCT07868497 · METvsSOR
Effects of Virtual Reality Exergames Versus Spinal Manipulation in Chronic Nonspecific Low Back Pain New · week 1randomised, double-blind
Spinal Manual Therapy Under Sedation New · week 1randomised, double-blind
Schweinhardt PetraCountry not stated · 20 participants · Not yet recruiting · primary completion 1 Apr 2029
RCT
NCT07858747 · MUS
Strain Counter Strain and Muscle Energy Technique in Non-specific Low Back Pain New · week 1randomised, double-blind
Riphah International UniversityPakistan · 62 participants · Recruiting · primary completion 1 Nov 2026
RCT · Registered after start
Telerehabilitation After Lumbar Disc Herniation Surgery New · week 1randomised
Hasan Kalyoncu UniversityTurkey (Türkiye) · 82 participants · Completed · primary completion 1 Oct 2026
RCT · Registered after completion
Comparative Effects Of Exercises Targeting Upper Trapezius In Patients With Non Specific Neck Pain New · week 1randomised
University of Management and Technology LahorePakistan · 34 participants · Not yet recruiting · primary completion 31 Dec 2026
RCT
Study on the Effect of Electronic Moxibustion on Non-Specific Low Back Pain in Young Adults New · week 1randomised
Nanfang Hospital, Southern Medical UniversityChina · 90 participants · Not yet recruiting · primary completion Sep 2027
RCT · Drug / biologic
Ultrasound-Guided Electrical Dry Needling for Chronic Cervical Radiculopathy New · week 1randomised
Liberty UniversityUnited States · 58 participants · Recruiting · primary completion Dec 2027
RCT
Use of Ultrasound Imaging in Confirming Osteopathic Spinal Diagnosis New · week 1Observational (case control)
The Touro College and University SystemUnited States · 35 participants · Completed · primary completion 26 Jun 2026
Registered after completion
Agreement Between CSI and IASP Pain Classification in Chronic Cervical Myofascial Pain New · week 1Observational (case only)
Mardin Artuklu UniversityTurkey (Türkiye) · 150 participants · Not yet recruiting · primary completion 15 Jun 2027
Comparative Study Between Proprioceptive Neuromuscular Facilitation and Post-facilitation Stretching in Text Neck Syndrome New · week 1randomised
Cairo UniversityCountry not stated · 51 participants · Not yet recruiting · primary completion 20 Apr 2027
RCT
NCT07887711 · TNS
Effects of Mental Participation During Lumbar Stabilization and Neuromuscular Electrical Stimulation in Chronic Non-Specific Low Back Pain New · week 1randomised
Istanbul University - CerrahpasaTurkey (Türkiye) · 35 participants · Completed · primary completion 1 May 2022
RCT · Registered after completion
The Intervention Effect of Exercise on Lumbar Multifidus Muscle Injuries New · week 1single arm
Chinese PLA General HospitalChina · 40 participants · Recruiting · primary completion May 2027
Effects of Strain Counterstrain Versus Post Isometric Relaxation on Pain, Headache Frequency, and Quality of Life in Females With Cervicogenic Headache. New · week 1randomised
Qurat Ul Ain AshfaqPakistan · 34 participants · Completed · primary completion 10 Jun 2026
RCT · Registered after completion
NCT07897695 · SCS-PIR
Preventing the Transition From Acute to Persistent Disabling Low Back Pain Through Cognitive Functional Therapy New · week 1randomised, double-blind
University of OuluFinland · 461 participants · Not yet recruiting · primary completion Sep 2029
RCT · n ≥ 200
NCT07877454 · FIN-BACK
Comparative Effects of Soft Tissue Mobilization and Pressure Therapy With and Without Dynamic Cupping on on Pain and Disability in Patients With Thoracic Back Pain. New · week 1randomised
University of Management and Technology LahorePakistan · 64 participants · Not yet recruiting · primary completion 31 Dec 2026
RCT
Comparative Effect Between Mulligan Leg Raise and Spinal Mobilization With Limb Movement in Lumbar Radiculopathy New · week 1randomised
Foundation University IslamabadPakistan · 44 participants · Recruiting · primary completion 1 Jan 2027
RCT
Comparison of the Effectiveness of Motor Imagery Exercises and Suboccipital Myofascial Release Techniques in Nonspecific Chronic Neck Pain New · week 1randomised
Ankara Yildirim Beyazıt UniversityTurkey (Türkiye) · 51 participants · Not yet recruiting · primary completion Jan 2028
RCT
NCT07883915 · MI-SMR-NSCNP
Correlation Between Trunk Muscles Endurance and Dynamic Balance in Sacroiliac Joint Dysfunction New · week 1Observational (case only)
Deraya UniversityEgypt · 46 participants · Not yet recruiting · primary completion 15 Feb 2027
Gyrokinesis for Chronic Nonspecific Neck Pain New · week 1randomised
Buddhist Tzu Chi General HospitalTaiwan · 46 participants · Completed · primary completion 30 Dec 2022
RCT · Registered after completion
Trapezius Oxygenation and Cervical Function in Chronic Neck Pain New · week 1Observational (cohort)
Kirsehir Ahi Evran UniversitesiTurkey (Türkiye) · 40 participants · Not yet recruiting · primary completion 5 Nov 2026
Effect of Excercises on Pain , Disability and Craniovertebral Angle in Patients With Forward Head Posture. New · week 1randomised
University of Management and Technology LahorePakistan · 36 participants · Not yet recruiting · primary completion 31 Dec 2026
RCT
Neck and Shoulder Pain in Homemakers New · week 1Observational (other)
Lokman Hekim UniversityTurkey (Türkiye) · 100 participants · Completed · primary completion 1 Aug 2026
Registered after completion
Gamified Home-Based Core Neuromuscular Training for Chronic Low Back Pain New · week 1randomised
Princess Nourah Bint Abdulrahman UniversityCountry not stated · 60 participants · Not yet recruiting · primary completion 20 Feb 2027
RCT
Pain Catastrophizing, Fear of Movement, and Physical Activity in Postmenopausal Women With Chronic Low Back Pain New · week 1Observational (other)
Istanbul Medipol University HospitalTurkey (Türkiye) · 150 participants · Recruiting · primary completion 1 Dec 2026
Effects of Instrument-Assisted Soft Tissue Mobilization Versus Post Facilitation Stretch Technique in Chronic Neck Pain New · week 1randomised
Foundation University IslamabadPakistan · 38 participants · Recruiting · primary completion 18 Dec 2026
RCT · Registered after start
Effects of Mobilization With and Without Suboccipital Muscle Release on Pain, Range of Motion, and Disability in Mechanical Neck Pain New · week 1randomised
University of Management and Technology LahorePakistan · 36 participants · Not yet recruiting · primary completion 31 Dec 2026
RCT
Effects of Dead Bug Exercises With and Without Diaphragmatic Breathing in Patients With Chronic Non-specific Low Back Pain. New · week 1randomised
University of Management and Technology LahorePakistan · 34 participants · Not yet recruiting · primary completion 31 Dec 2026
RCT
Cervical Stabilization vs Scapular Clock Exercises for Chronic Non-Specific Neck Pain New · week 1randomised
University of Management and Technology LahorePakistan · 30 participants · Active, not recruiting · primary completion 31 Dec 2026
RCT
Effects of Modified Clamshell Training Versus Sling System Training on Pain, Functional Disability, and SIJ Nutation Control in Postpartum Women With SIJ Dysfunction New · week 1randomised
Dr Aneeqa SultanPakistan · 36 participants · Completed · primary completion 27 May 2026
RCT · Registered after completion
NCT07852741 · MCT-SST
EFFECTS OF EXERCISE AND EXERCISE COUNSELLING IN PATIENTS WITH LUMBAR SPINAL STENOSIS New · week 1randomised
University Medical Centre LjubljanaSlovenia · 87 participants · Completed · primary completion 21 Jun 2025
RCT · Registered after completion
Surface Electromyographic Analysis of Scapular Stabilizer Muscle in Postural Hyperkyphosis New · week 1randomised
Istinye UniversityTurkey (Türkiye) · 50 participants · Not yet recruiting · primary completion 15 Jan 2027
RCT
Effects of a Classroom-Integrated Exercise Program on Neck Health and Performance in Dental Students New · week 1non-randomised
Giresun UniversityCountry not stated · 64 participants · Not yet recruiting · primary completion 27 Nov 2026
Kinesio Taping in Young Adults With Thoracic Hyperkyphosis New · week 1randomised, double-blind
Istinye UniversityTurkey (Türkiye) · 40 participants · Recruiting · primary completion 15 Dec 2026
RCT
Evaluation of Sarcopenia and Muscle Biomechanics in Older Adults After Lumbar Fusion Surgery New · week 1Observational (case control)
Karamanoğlu Mehmetbey UniversityTurkey (Türkiye) · 51 participants · Completed · primary completion 1 Sep 2026
Registered after completion
Hybrid mHealth for Low Back Pain New · week 1randomised
The Hong Kong Polytechnic UniversityHong Kong · 60 participants · Not yet recruiting · primary completion 2 Nov 2027
RCT
H-Reflex-Guided Direction-Sensitive Exercise Versus Standard Extension Exercise for Functional Recovery in Patients With Lumbar Disc Prolapse New · week 1randomised, double-blind
Delta University for Science and TechnologyEgypt · 60 participants · Not yet recruiting · primary completion 5 Oct 2026
RCT
Kinesiology Taping Versus Self-Mobilization for Neck Pain Related to Prolonged Electronic Device Use New · week 1randomised
Istanbul University - CerrahpasaTurkey (Türkiye) · 27 participants · Recruiting · primary completion 13 Nov 2026
RCT · Device
Dual-Task Core Stabilization Training in Chronic Nonspecific Low Back Pain New · week 1randomised
Karabuk UniversityTurkey (Türkiye) · 90 participants · Not yet recruiting · primary completion 1 Feb 2027
RCT
NCT07894965 · DT-CSE
Effects of Motor Control Exercises With and Without Pressure Biofeedback in Recurrent Low Back Pain (MCE) New · week 1randomised
University of Management and Technology LahorePakistan · 48 participants · Not yet recruiting · primary completion 31 Dec 2026
RCT
NCT07892079 · yes
Pain Neuroscience Education and Neuromuscular Exercise in Individuals With Chronic Low Back Pain and Central Sensitization New · week 1randomised
Izmir Katip Celebi UniversityTurkey (Türkiye) · 66 participants · Not yet recruiting · primary completion Apr 2027
RCT
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Results posted on ClinicalTrials.gov
Spine trials whose results were first posted on ClinicalTrials.gov in October 2026, with the primary outcome as posted. Registry results are not peer reviewed.
Pain reprocessing therapy for chronic back pain3-arm RCT
Weill Medical College of Cornell University · 3-arm RCT · 165 adults
Average pain (0 to 10) fell from about 5.5 at baseline to 2.28 after pain reprocessing therapy, against 4.33 after cognitive-behavioural therapy for chronic pain and 4.84 with usual care. Posted net differences for pain reprocessing therapy were −2.01 (95% CI −2.65 to −1.37) against CBT and −2.59 (−3.22 to −1.95) against usual care, both p<0.001.
A large short-term effect in a racially and ethnically diverse sample; the primary time point was the end of treatment, about 6 weeks.
Adherus versus DuraSeal Exact dural sealant in spinal surgeryRCT
Stryker Craniomaxillofacial · RCT · 94 patients
Freedom from CSF leak, pseudomeningocele or device-related reoperation at 90 days was 95.5% with Adherus and 92.1% with DuraSeal Exact (difference 2.2 points, 95% CI −18.3 to 24.8). Serious adverse events: 10 of 50 against 7 of 44.
The sponsor reports non-inferiority against a 13-point margin (one-sided p=0.001), yet the posted confidence interval crosses that margin; worth reading the full analysis.
Sugammadex versus neostigmine reversal and urinary retention after lumbar surgeryPhase 4 RCT
University of Missouri-Columbia · Phase 4 RCT · 118 patients
Urinary retention within 6 hours affected 2 of 62 patients after sugammadex and 6 of 56 after neostigmine with glycopyrrolate. No between-group statistics are posted.
Single centre and lumbar surgery only; the investigators note bladder scans were not available for every patient at 6 hours.
Neuromonitoring alerts during spinal deformity surgerysingle arm
AO Foundation, AO Spine · single arm · 592 patients
84 of 555 patients analysed (15%) had at least one major intraoperative neuromonitoring alert (more than half the SSEP or MEP amplitude lost, or sustained EMG activity); operations lasted 6.3 hours on average.
An international prospective series; the posted primary measure is alert incidence, not neurological outcome.
Soft back exosuit to prevent work-related low back painRCT
Wyss Institute at Harvard University · RCT · 97 workers
Work-interfering back discomfort scores were lower with the exosuit than without at each monthly survey (for example 1.0 against 2.0 at month 3), with wide spread. By month 4, new low back discomfort had been reported by 3 of 58 exosuit users against 6 of 29 controls.
Fewer workers enrolled than planned and outcomes were self-reported; the registry links a paper (PubMed 42878865).
Osteopathic manipulation and head–neck control in chronic neck paincrossover RCT
Michigan State University · crossover RCT · 154 participants
Osteopathic manipulative treatment did not improve head position or force tracking, head stabilisation, neck force variability or muscle activation patterns compared with no intervention (posted p values 0.075 to 0.985).
A null mechanistic result; no serious adverse events in any group.
Sleep disruption and response to an opioid in chronic low back painnon-randomised crossover
Johns Hopkins University · non-randomised crossover · 109 enrolled
Data are posted for only 5 participants with chronic low back pain in each sleep condition, alongside 20 to 21 healthy controls: mean drug liking was 22.2 after uninterrupted sleep and 16.4 after disrupted sleep, and heat pain thresholds were 42.1 and 41.4 °C.
Too few patients analysed to draw conclusions, and no statistical comparisons are posted.
Blood pressure surges during bladder and bowel testing after spinal cord injuryobservational
University of Louisville · observational · 57 participants
Systolic blood pressure rose by more than 20 mmHg during bladder filling in 51 of 56 participants, and during anorectal manometry in 48 of 56.
Autonomic dysreflexia during routine bladder and bowel testing was the rule rather than the exception in this group.
Pressure-mapping app to prevent sitting pressure injuries in SCInon-randomised
VA Office of Research and Development · non-randomised · 43 participants
Veterans with SCI rated usability of the CMAP system at 80.4 and 82.5 on the System Usability Scale two years apart during development, 83.0 after 10 days in hospital and 85.8 after 3 weeks at home (from 76.3 at the start of home use). No adverse events.
A usability development study with groups of 2 to 7 people.
Neck muscle changes after whiplash injurysingle arm
Northwestern University · single arm · 97 participants
The posted primary measure is only the number of participants who had MRI for neck muscle fat: 97 at each early time point and 78 at one year.
No outcome data in the registry; the findings are in linked papers (PubMed 39972963, 37099498, 36958668, 34705736).
Trial reports added to PubMed
Randomised and registered clinical trials in spine added to PubMed in October, one line each from the abstract. Summaries are based on abstracts only.
Surgery & implants7
Robot-assisted MIS TLIF versus open fluoroscopy-guided TLIF New · week 1Assessor-blinded RCT, 128 patients (1:3)
Wang et al. · J Robot Surg · PubMed 42955165 · ChiCTR2400082553
Assessor-blinded RCT, 128 patients (1:3). ODI was slightly better at 2 weeks but not at 3 months, below the planned difference; screw placement was more accurate and stay shorter, with longer operations.
Transfascial paraspinal versus open pedicle screw fixation for thoracolumbar fractures New · week 1RCT
Saini et al. · Cureus · PubMed 42871773 · registration not given in abstract
RCT. Shorter operations, less blood loss, earlier mobilisation and lower pain up to 12 months with the transfascial approach; correction was similar.
Adding S2 fixation to L4–S1 fusion in high-grade spondylolisthesis New · week 1Single-centre randomised study, 70 patie
Basiony et al. · Spine (Phila Pa 1976) · PubMed 42832654 · registration not given in abstract
Single-centre randomised study, 70 patients. Lower pain and ODI and no S1 screw breakage with S2 extension; fusion and pull-out differences were not significant.
Wound dehiscence after biportal endoscopic versus microscopic lumbar decompression New · week 1Post hoc analysis of two RCTs, 211 patie
Park et al. · Neurosurg Focus · PubMed 42822040 · registration not given in abstract
Post hoc analysis of two RCTs, 211 patients. All 9 dehiscences were in the microscopic group; incision length of 35 mm or more and high drain output were the main risk factors.
Long-term dysphagia after multilevel anterior surgery for cervical myelopathy (CSM-Protect) New · week 1Secondary analysis of a phase III trial,
Bak et al. · J Neurosurg Spine · PubMed 42854252 · registration not given in abstract
Secondary analysis of a phase III trial, 132 patients. Dysphagia peaked at 35 days and still affected about a third at 1 year; C5 involvement and baseline dysphagia predicted persistence.
Smartphone LiDAR measurement to locate the level for vertebroplasty New · week 1RCT, 43 patients with osteoporotic fract
Wang et al. · J Vis Exp · PubMed 42841539 · registration not given in abstract
RCT, 43 patients with osteoporotic fractures. Localisation was quicker with fewer fluoroscopy images; accuracy and 3-month pain and ODI did not differ.
b.Bone graft extender in posterolateral thoracolumbar fusion (b.Spine) New · week 1Pre-market single-arm study, 15 patients
Tedesco et al. · Front Bioeng Biotechnol · PubMed 42857381 · registration not given in abstract
Pre-market single-arm study, 15 patients. Fusion in 10 of 15 at 6 months and all by 12 months; no adverse events were judged device-related.
Perioperative care15
Deep versus moderate neuromuscular block and chronic pain after lumbar surgery New · week 1RCT, 180 randomised
Wang et al. · Anesth Analg · PubMed 42848950 · registration not given in abstract
RCT, 180 randomised. Chronic postsurgical pain at 3 months was less common with deep block (19% against 35%) but not significantly different at 6 months; MRI showed better paraspinal muscle preservation.
Tranexamic acid and the endoscopic view in full-endoscopic discectomy New · week 1RCT, 58 patients
Meira et al. · Neurosurg Focus · PubMed 42822046 · registration not given in abstract
RCT, 58 patients. Visualisation was rated high in both groups with no difference from tranexamic acid; no thromboembolic events.
Esketamine added to patient-controlled analgesia after lumbar decompression New · week 1Dose-finding RCT, 120 patients
Liu et al. · Front Pharmacol · PubMed 42952698 · ChiCTR2500095890
Dose-finding RCT, 120 patients. All esketamine regimens lowered pain and opioid use; the highest dose brought more hypotension and dissociative symptoms.
Sodium oxybate with reduced propofol at induction for spine surgery New · week 1RCT, 127 patients
Yu et al. · Front Med (Lausanne) · PubMed 42948135 · ChiCTR2400080686
RCT, 127 patients. Blood pressure during induction did not differ; about a third less propofol was used, with a slightly longer time to extubation.
Erector spinae plane block in posterior cervical spine surgery New · week 1RCT (Chinese, English abstract), 60 comp
Jiang et al. · Zhong Nan Da Xue Xue Bao Yi Xue Ban · PubMed 42935201 · registration not given in abstract
RCT (Chinese, English abstract), 60 completed. Less intraoperative opioid, lower pain to 48 hours and better quality-of-recovery scores than general anaesthesia alone.
Dexmedetomidine with oxycodone PCA after lumbar fusion: haemodynamic effects New · week 1Post hoc analysis of an RCT
Mäkelä et al. · Acta Anaesthesiol Scand · PubMed 42929478 · NCT02454881 · EudraCT 2014-003252-31
Post hoc analysis of an RCT. Blood pressure and heart rate fell transiently, resolving by 48 hours; no bradycardia and no respiratory differences.
Epidural gelfoam soaked in morphine versus dexamethasone after lumbar discectomy New · week 1RCT, 60 patients
Kaloria et al. · Asian J Neurosurg · PubMed 42857464 · registration not given in abstract
RCT, 60 patients. Time to first analgesic did not differ; more patients needed no rescue analgesia in the first 24 hours with morphine.
Open-label placebo injections for pain after lateral lumbar fusion (OLP-POP) New · week 1RCT, 65 older patients
Sezer et al. · Pain Rep · PubMed 42872255 · registration not given in abstract
RCT, 65 older patients. Morphine use over 48 hours did not differ from usual care.
Transcutaneous electrical acustimulation for bowel recovery after multilevel lumbar surgery New · week 1Sham-controlled RCT, 50 patients
Song et al. · J Neurogastroenterol Motil · PubMed 42954014 · registration not given in abstract
Sham-controlled RCT, 50 patients. Earlier first flatus and defecation and fewer gastrointestinal symptoms with active stimulation.
Videolaryngoscopy versus Macintosh laryngoscopy: neck movement in cervical spine surgery New · week 1RCT, 56 patients
Doan et al. · Braz J Anesthesiol · PubMed 42880586 · registration not given in abstract
RCT, 56 patients. Less upper cervical and cumulative C0–C5 movement with videolaryngoscopy; the authors stress this is a surrogate, not proof of neurological protection.
Electrical stimulation added to early mobilisation after lumbar discectomy New · week 1RCT, 60 patients
Yıldırım et al. · Am J Phys Med Rehabil · PubMed 42839315 · registration not given in abstract
RCT, 60 patients. Greater gains in pain, ODI, walking and strength with the combined programme.
Personalised education with the CICARE communication model after UBE surgery New · week 1RCT, 120 patients
Li et al. · Int J Orthop Trauma Nurs · PubMed 42945902 · registration not given in abstract
RCT, 120 patients. Better self-efficacy, anxiety, pain and ODI scores, earlier walking and shorter stay.
Structured perioperative nursing pathway for lumbar fusion New · week 1Non-randomised, non-concurrent controlle
Song et al. · J Orthop Surg Res · PubMed 42958305 · registration not given in abstract
Non-randomised, non-concurrent controlled study, 140 patients. Lower pain at discharge and shorter stay; later differences were exploratory.
Patient–spouse psychological support around surgery for spinal metastases New · week 1RCT, 88 couples
Xie et al. · Front Public Health · PubMed 42908817 · registration not given in abstract
RCT, 88 couples. Lower distress in patients and spouses, most clearly 2 weeks after discharge.
Plain-language AI versions of spine imaging reports New · week 1RCT, 52 patients
Sampath et al. · Neurosurgery · PubMed 42910932 · registration not given in abstract
RCT, 52 patients. Rewritten reports were far easier to read and patients found the language easier to understand.
Deformity & paediatric4
Supervised scoliosis-specific exercise alongside bracing in AIS: 24-month results New · week 1RCT
Zhang et al. · Bone Joint J · PubMed 42966369 · registration not given in abstract
RCT. Supervised exercise reduced the Cobb angle by about 3° more than self-directed exercise, below the 5° clinically important threshold, with no meaningful quality-of-life gain.
Schroth versus core stabilisation exercise in AIS New · week 1RCT, 38 adolescents
Yildirim et al. · Am J Phys Med Rehabil · PubMed 42844659 · registration not given in abstract
RCT, 38 adolescents. Schroth gave larger improvements in Cobb angle, trunk rotation, respiratory strength and perceived deformity.
Adding breathing exercises (DNS) to Schroth in moderate idiopathic scoliosis New · week 1RCT, 26 analysed
Eyuboglu et al. · Biol Res Nurs · PubMed 42947470 · NCT06682702
RCT, 26 analysed. Lower pain and thoracic trunk rotation with the combination over 8 weeks.
Myofascial release with TENS for trunk rotation in AIS New · week 1Exploratory RCT, retrospectively registe
Liang et al. · Childs Nerv Syst · PubMed 42955351 · ChiCTR2400091231
Exploratory RCT, retrospectively registered. Trunk rotation fell by about 4° after one week; the authors call for larger, prospectively registered trials.
Spinal cord injury3
Brain–spine interface restores leg movement in motor-complete SCI New · week 1Early trial, 3 participants
Jiang et al. · Med · PubMed 42913645 · ChiCTR2500095359
Early trial, 3 participants. All regained brain-controlled leg movement from the first day after implantation and walked with body-weight support within 2 weeks.
iTBS or rTMS with robotic gait training in chronic incomplete SCI New · week 1Sham-controlled RCT, 30 patients
Kalem Ozgen et al. · Am J Phys Med Rehabil · PubMed 42839316 · registration not given in abstract
Sham-controlled RCT, 30 patients. Both active protocols were associated with larger 4-week gains in lower-limb motor score, independence and walking speed than sham, with no difference between them.
COMPANION eHealth tool for family caregivers after SCI New · week 1Feasibility RCT, 51 participants
Mohammadi et al. · Spinal Cord · PubMed 42816541 · NCT06364813
Feasibility RCT, 51 participants. Eight of 12 feasibility targets were met; outcomes did not differ between groups.
Neuromodulation1
HD-tDCS over the somatosensory cortex with core training for chronic low back pain New · week 1Sham-controlled RCT, 36 adults
Li et al. · BMC Neurol · PubMed 42963732 · ChiCTR2300076620
Sham-controlled RCT, 36 adults. Greater short-term reductions in pain and disability with active stimulation.
Interventional & injections2
Lateral-deployment versus conventional cannulas for lumbar medial branch radiofrequency ablation New · week 1Participant-blinded RCT, 84 analysed
Kahraman et al. · Am J Phys Med Rehabil · PubMed 42908078 · registration not given in abstract
Participant-blinded RCT, 84 analysed. At 6 months 74% against 38% had at least halved their pain with the lateral-deployment cannula.
Paravertebral ozone injections versus passive physical modalities with home exercise New · week 1Pilot RCT, 64 patients
Yousefi et al. · J Back Musculoskelet Rehabil · PubMed 42935354 · registration not given in abstract
Pilot RCT, 64 patients. No significant difference in disability or pain up to 6 months.
Medicines3
Intravenous ibuprofen versus ketorolac for acute low back pain in the emergency department New · week 1Triple-blind RCT, 73 patients
Jafarkhani et al. · Intern Emerg Med · PubMed 42902081 · registration not given in abstract
Triple-blind RCT, 73 patients. Lower pain at 10 and 30 minutes and shorter stay with ibuprofen; side effects were similar.
Ushaq herbal capsules added to usual care for lumbar radiculopathy New · week 1Placebo-controlled RCT
Mardi et al. · Musculoskeletal Care · PubMed 42935088 · IRCT20200418047124N1
Placebo-controlled RCT. Pain fell more with Ushaq from week 2, but disability did not improve more than with placebo.
Jintiange capsules added to conventional care for lumbar disc herniation New · week 1Open-label RCT
Liang et al. · Front Pharmacol · PubMed 42922992 · ChiCTR2300069735
Open-label RCT. Better JOA scores and several secondary outcomes over 8 weeks; the open design limits conclusions.
Rehab & conservative care18
Photobiomodulation added to motor control exercise for chronic low back pain New · week 1Sham-controlled RCT, 148 patients
Tomazoni et al. · J Physiother · PubMed 42864195 · NCT05487118
Sham-controlled RCT, 148 patients. No clinically important added effect on pain, disability or PGE2 at any point up to 12 months.
AI-enabled telerehabilitation for chronic neck pain New · week 1Multicentre non-inferiority RCT, 116 pat
Zhao et al. · JMIR Form Res · PubMed 42879432 · registration not given in abstract
Multicentre non-inferiority RCT, 116 patients. Home telerehabilitation was non-inferior to clinic-based exercise on neck disability at 24 weeks.
EPIC-Neck co-developed exercise for chronic neck pain (UK feasibility) New · week 1Multicentre feasibility RCT, 36 randomis
Price et al. · BMJ Open · PubMed 42901578 · ISRCTN81746901
Multicentre feasibility RCT, 36 randomised. Recruitment was adequate but retention (67%) and delivery fidelity were short of targets; a full trial needs refinement first.
Open-label placebo and expectations in chronic low back pain New · week 1RCT, 130 patients
Winkler et al. · Psychother Psychosom · PubMed 42821491 · registration not given in abstract
RCT, 130 patients. Open-label placebo with observational learning gave pain relief that did not differ significantly from active medication; higher expectations predicted greater relief.
Hidden conditioning and expectations with spinal manipulation for low back pain New · week 1Three-arm RCT
Nogueira Carrer et al. · Eur J Pain · PubMed 42862041 · NCT05202704
Three-arm RCT. No difference in pain or global improvement between the conditioning and expectation groups.
Manipulation, exercise and open-label placebo: immediate effects on lifting New · week 1Crossover RCT, 50 participants
Borg et al. · Chiropr Man Therap · PubMed 42875790 · NCT06891625
Crossover RCT, 50 participants. Limited immediate effects on lifting, with no between-group difference at the primary endpoint.
Internet-supported neck exercise for chronic whiplash: cost-effectiveness New · week 1Economic analysis of an RCT
Kshirsagar et al. · J Med Internet Res · PubMed 42950242 · NCT03022812
Economic analysis of an RCT. The internet version cost less but gave slightly lower quality of life at 15 months.
Stress inoculation training with exercise for acute whiplash: cost-effectiveness New · week 1Economic analysis of an RCT
Papic et al. · J Physiother · PubMed 42850195 · ACTRN12614001036606
Economic analysis of an RCT. Likely cost-effective from a health-system view, but with higher societal costs.
Three versus one electroacupuncture session a week for chronic neck pain New · week 1RCT, 90 young adults
Tu et al. · J Pain Res · PubMed 42827973 · ITMCTR2025001658
RCT, 90 young adults. Both beat waiting list; three sessions gave more short-term benefit, which mostly faded by follow-up.
Needle-knife therapy versus acupuncture for lumbar disc herniation New · week 1Assessor-blinded RCT, 74 patients
Zhang et al. · Front Neurol · PubMed 42964068 · ITMCTR2025002191
Assessor-blinded RCT, 74 patients. Larger improvements in pain and ODI with needle-knife, sustained at 3 months.
Pilates with cognitive functional therapy for chronic low back pain in women New · week 1Three-arm RCT, 120 women
Yalfani et al. · Pain Med · PubMed 42895859 · registration not given in abstract
Three-arm RCT, 120 women. Adding CFT did not improve pain or disability beyond Pilates alone but helped kinesiophobia and trunk endurance.
Hip strengthening added to lumbar motor control for chronic low back pain New · week 1RCT, 54 adults
Rodríguez-López et al. · Sports (Basel) · PubMed 42931593 · registration not given in abstract
RCT, 54 adults. Both groups improved, with no between-group difference in pain or disability.
Percussive vibration added to physiotherapy for chronic low back pain New · week 1RCT, 50 adults
Bayraktar et al. · J Clin Med · PubMed 42882172 · registration not given in abstract
RCT, 50 adults. No added benefit for disability (the primary outcome) or sleep.
Resistance versus aerobic training for chronic low back pain New · week 1RCT, 38 participants
Mohammed et al. · Physiother Res Int · PubMed 42908089 · NCT06922981
RCT, 38 participants. Resistance training gave lower pain, disability and kinesiophobia after 8 weeks.
Deep versus superficial dry needling for neck pain New · week 1Triple-blind RCT, 44 participants
Alhakami et al. · Biosensors (Basel) · PubMed 42930130 · registration not given in abstract
Triple-blind RCT, 44 participants. Both improved pain and disability, with no clinical difference between them.
Exosuits and back discomfort in warehouse workers New · week 1RCT, 97 workers
Quirk et al. · Ergonomics · PubMed 42878865 · NCT05802914
RCT, 97 workers. No difference by intention to treat; in exploratory analysis moderate users had less back discomfort.
Shock wave therapy versus ultrasound with exercise in ankylosing spondylitis New · week 1Assessor-blinded RCT, 106 patients
Elmotaleb Gazar et al. · Musculoskeletal Care · PubMed 42830430 · registration not given in abstract
Assessor-blinded RCT, 106 patients. Better function at 12 months with shock waves; pain and disease activity did not differ. Not prospectively registered.
Kinesio taping with exercise for low back pain in pregnancy New · week 1Sham-controlled RCT
Akcan et al. · Niger J Clin Pract · PubMed 42937386 · registration not given in abstract
Sham-controlled RCT. Slightly more pain relief with taping; disability rose in both groups as pregnancy progressed.
Protocols published11
RESTORES: epidural stimulation with personalised rehabilitation in chronic motor-complete SCI (single-arm phase II) Front Neurol · PubMed 42921395 · NCT05644171
Front Neurol · PubMed 42921395 · NCT05644171
Alpha transcranial alternating current stimulation for recovery after lumbar fusion BMJ Open · PubMed 42957298 · ChiCTR2600122565
BMJ Open · PubMed 42957298 · ChiCTR2600122565
Remimazolam versus propofol and cerebral oxygenation in older patients having prone spine surgery BMJ Open · PubMed 42843860 · jRCT1031250782
BMJ Open · PubMed 42843860 · jRCT1031250782
Electroacupuncture added to usual care for acute lumbar disc herniation (multicentre, sham-controlled) BMJ Open · PubMed 42849958 · ITMCTR2025002522
BMJ Open · PubMed 42849958 · ITMCTR2025002522
Jintiange capsules for lumbar disc herniation Pain Res Manag · PubMed 42958764 · ChiCTR2300069735
Pain Res Manag · PubMed 42958764 · ChiCTR2300069735
Electroacupuncture for painful cervical spondylotic radiculopathy Pain Manag · PubMed 42960749 · ChiCTR2300075726
Pain Manag · PubMed 42960749 · ChiCTR2300075726
Ultrasound-guided acupotomy for degenerative cervical radiculopathy J Pain Res · PubMed 42903877 · KCT0011139
J Pain Res · PubMed 42903877 · KCT0011139
TeleBACK: telerehabilitation versus in-clinic physiotherapy for chronic low back pain BMJ Open · PubMed 42901559 · NCT06821607
BMJ Open · PubMed 42901559 · NCT06821607
Eye movement exercise with physiotherapy for chronic neck pain Front Sports Act Living · PubMed 42952750 · ChiCTR2500111782
Front Sports Act Living · PubMed 42952750 · ChiCTR2500111782
PosturePals for cervicothoracic pain syndrome Curr Protoc · PubMed 42949569 · CTRI/2025/01/079689
Curr Protoc · PubMed 42949569 · CTRI/2025/01/079689
Prone spinal decompression with McKenzie exercises for lumbar radiculopathy J Educ Health Promot · PubMed 42924338 · registration not given in abstract
J Educ Health Promot · PubMed 42924338 · registration not given in abstract
Stopped early or withdrawn
Spine trials whose registry entry changed to terminated or withdrawn in October, with the reason the investigators gave. A trial that never recruited still tells you a question is unanswered.
Peripheral nerve stimulation versus radiofrequency ablation for facet joint pain New · week 1Withdrawn (0 enrolled)
NCT05952518 · Penn State University
Reason given: Recruitment proved difficult; the study is being closed.
Braive growth modulation system for juvenile and adolescent idiopathic scoliosis New · week 1Terminated (10 enrolled)
NCT04929678 · Medtronic Spinal and Biologics
Reason given: Stopped once every active participant had met all primary endpoints at 24 months; the sponsor has no plans to use the data for regulatory approval. Results posted.
Burst spinal cord stimulation for chronic pain after back surgery New · week 1Terminated (12 enrolled)
NCT03718325 · University of Michigan
Reason given: Data quality and protocol problems: sham stimulation settings were inadequate and blinding was compromised. Results posted.
Predictors of persistent pain and opioid misuse after spine surgery New · week 1Terminated (60 enrolled)
NCT06288256 · Icahn School of Medicine at Mount Sinai
Reason given: The principal investigator left the institution.
Predictors of persistent pain and opioid misuse in chronic back pain New · week 1Terminated (130 enrolled)
NCT06288282 · Icahn School of Medicine at Mount Sinai
Reason given: The principal investigator left the institution.
VIA Disc NP registry for discogenic back pain New · week 1Terminated (83 enrolled)
NCT04652687 · VIVEX Biologics, Inc.
Reason given: Sponsor decision; no further detail given.
Medial branch block versus paraspinal muscle injection for chronic low back pain New · week 1Terminated (8 enrolled)
NCT02521519 · McGill University Health Centre
Reason given: No reason given in the registry.
Dextrose prolotherapy for low back pain in hypermobile Ehlers-Danlos syndrome New · week 1Withdrawn (0 enrolled)
NCT05279937 · Tulane University
Reason given: The study was not funded.
Tamibarotene for HTLV-1-associated myelopathy New · week 1Terminated (15 enrolled)
NCT01343355 · St. Marianna University School of Medicine
Reason given: Lack of efficacy. The trial ran in 2011; the registry entry was updated in October.
Accuracy of pedicle screws placed with the Mazor robotic system against the plan New · week 2Terminated (50 enrolled)
NCT05884593 · Ohio State University
Reason given: Study activities were completed, but the final analysis could not be done because of operational disruption caused by the war in Gaza. Registry entry updated in October; the status change itself may be earlier.
Functional electrical stimulation for spasticity, quadriceps strength and mobility in paraplegia New · week 2Withdrawn (0 enrolled)
NCT07583576 · Istanbul Medipol University Hospital
Reason given: The investigator running the trial relocated, and logistics made it impossible to continue. Registry entry updated in October; the status change itself may be earlier.
Recently completed, results awaited
28 interventional spine trials completed between July and October 2026 whose registry entries were updated in October. None has posted results yet. We will report them here when they do.
Implementation of the ACP Guideline for Low Back Pain (IMPACt-LBP) New · week 1randomised
Alberta Back Care Pathway (ABCp) New · week 1Phase 2, non-randomised
Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain New · week 1Early Phase 1, randomised, double-blind
Baduanjin With Resistance Training Program New · week 1randomised
Intertransverse Process Block Versus Erector Spinae Plane Block for Pain Relief in Lumbar Spine Surgery New · week 1randomised
Telerehabilitation After Lumbar Disc Herniation Surgery New · week 1randomised
Effects of Close Follow-up on Patients With Low Back Pain New · week 1randomised
Effect of Body Mind Exercises and Specific Neck Exercises in Chronic Mechanical Neck Pain New · week 1randomised
ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound New · week 1randomised
Feedback-Based Balance Training for Adolescents With Idiopathic Scoliosis New · week 1randomised
Contextual Effects on Inflammatory Biomarkers and Pain Relief After Spinal Joint Manipulation New · week 1randomised, triple-blind
Therapeutic Effects of Instrument-assisted Versus Sound-assisted Soft Tissue Mobilization in Chronic Non-specific Low Back Pain New · week 1randomised, double-blind
Safety and Efficacy of Subdermal Betadine During Posterior Spinal Fusion New · week 1Phase 4, randomised, double-blind
Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography New · week 1randomised
NCT07325812 · Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization · Turkey (Türkiye)
n: 60
Completed: 28 Aug 2026
The Long Term Effects of Online Therapeutic Neuroscience Education in Patients With Chronic Low Back Pain New · week 1randomised
Effect of Shock Wave Therapy With Core Stability Exercises for Treatment of Chronic Non-Specific Back Pain New · week 1randomised
The Effect of Dexamethasone Administration Route and Local Anesthetic Concentration on Pain, Inflammatory Response, and Neuromonitoring in Children Undergoing Scoliosis Correction New · week 1Phase 4, randomised, quadruple-blind
Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery New · week 1randomised
Effects of Telerehabilitation and Supervised Clinic Based Rehab With Pain Neuroscience Education for Pain,Kinesiophobia and Functional Disability Among Chronic Non-Specific Neck Pain Patients New · week 1randomised
NCT07617623 · Lahore University of Biological and Applied Sciences · Pakistan
n: 48
Completed: 31 Jul 2026
Effects of Pelvic Floor Exercises and Muscle Energy Techniques on Pain and Disability in Sacroiliac Joint Dysfunction New · week 1randomised, triple-blind
NCT07275294 · Lahore University of Biological and Applied Sciences · Pakistan
n: 46
Completed: 27 Oct 2026
The Effectiveness of Aquatherapy on Physical Performance and Fear of Falling in Geriatric Individuals With Low Back Pain New · week 1randomised
IASTM and Vibration Effects on Pain, Functionality, and Kinesiophobia in Lumbar Disc Herniation New · week 1randomised
Acute Effects of Classical vs. Percussive Massage on Text Neck Syndrome New · week 1randomised
The Effects of Dynamic Taping Combined With Corrective Exercises on Cervical Proprioception and Muscle Imbalance in Patients With Upper Crossed Syndrome New · week 1randomised
Effects of Strain Counterstrain Versus Post Isometric Relaxation on Pain, Headache Frequency, and Quality of Life in Females With Cervicogenic Headache. New · week 1randomised
Multi-Omics Characterization of Percutaneous Electrolysis in Low Back Pain New · week 1randomised
Effects of Music Therapy in Chronic Neck Pain New · week 1single arm
Evaluation of the Comfort Increase Provided by an Additional Foam Pad on a Lumbar Belt and Its Biophysical Impact New · week 1randomised
How we compile this page
| Source | ClinicalTrials.gov, searched for spine and spinal cord terms by the date a record was first posted (new trials), the date results were first posted, and the date the record was last updated (status changes). Trial reports come from PubMed, by date added, as in Literature Watch. |
|---|---|
| Scope | Anything dedicated to the spine or spinal cord: surgery and implants, perioperative care, injections, rehabilitation, drugs and biologics, spinal cord injury and spinal cord stimulation. We leave out studies where the spine is only incidental, such as spinal anaesthesia for other operations, lumbar puncture, nerve blocks for non-spine surgery and general osteoporosis. |
| Europe | European trials appear here only if they are also on ClinicalTrials.gov. We have not yet swept the EU Clinical Trials Information System (drug trials), the German Clinical Trials Register (DRKS) or the WHO registry portal. EUDAMED, where device investigations will be registered, is not yet fully live. European coverage is therefore incomplete. |
| Flags | "Registered after start" means the record was first posted more than 60 days after the study began. "Registered after completion" means the trial was already finished when it was registered. |
| Not advice | Listing a trial is not an endorsement, and a registered trial is not evidence that a treatment works. Check details with the registry before relying on them. |
Data retrieved 24 October 2026. Spotted a mistake or a trial we missed? Email spinalfrontiers@nspine.com.